Evaluation of a Phosphate Management Protocol to Achieve Optimum Serum Phosphate Levels in Hemodialysis Patients

Original article can be found at: http://www.sciencedirect.com/science/journal/10512276 Copyright National Kidney Foundation, Inc. DOI: 10.1053/j.jrn.2008.05.003To evaluate the effectiveness of a protocol designed to optimize serum phosphate levels in patients undergoing regular hemodialysis (HD).Peer reviewe

Chromosome 9p deletion in clear cell renal cell carcinoma predicts recurrence and survival following surgery

BACKGROUND: Wider clinical applications of 9p status in clear cell renal cell carcinoma (ccRCC) are limited owing to the lack of validation and consensus for interphase fluorescent in situ hybridisation (I-FISH) scoring technique. The aim of this study was to analytically validate the applicability of I-FISH in assessing 9p deletion in ccRCC and to clinically assess its long-term prognostic impact following surgical excision of ccRCC. METHODS: Tissue microarrays were constructed from 108 renal cell carcinoma (RCC) tumour paraffin blocks. Interphase fluorescent in situ hybridisation analysis was undertaken based on preset criteria by two independent observers to assess interobserver variability. 9p status in ccRCC tumours was determined and correlated to clinicopathological variables, recurrence-free survival and disease-specific survival. RESULTS: There were 80 ccRCCs with valid 9p scoring and a median follow-up of 95 months. Kappa statistic for interobserver variability was 0.71 (good agreement). 9p deletion was detected in 44% of ccRCCs. 9p loss was associated with higher stage, larger tumours, necrosis, microvascular and renal vein invasion, and higher SSIGN (stage, size, grade and necrosis) score. Patients with 9p-deleted ccRCC were at a higher risk of recurrence (P=0.008) and RCC-specific mortality (P=0.001). On multivariate analysis, 9p deletion was an independent predictor of recurrence (hazard ratio 4.323; P=0.021) and RCC-specific mortality (hazard ratio 4.603; P=0.007). The predictive accuracy of SSIGN score improved from 87.7% to 93.1% by integrating 9p status to the model (P=0.001). CONCLUSIONS: Loss of 9p is associated with aggressive ccRCC and worse prognosis in patients following surgery. Our findings independently confirm the findings of previous reports relying on I-FISH to detect 9p (CDKN2A) deletion

A Coordinated Radio Afterglow Program

We describe a ground-based effort to find and study afterglows at centimeter and millimeter wavelengths. We have observed all well-localized gamma-ray bursts in the Northern and Southern sky since BeppoSAX first started providing rapid positions in early 1997. Of the 23 GRBs for which X-ray afterglows have been detected, 10 have optical afterglows and 9 have radio afterglows. A growing number of GRBs have both X-ray and radio afterglows but lack a corresponding optical afterglow.Comment: To appear in Proc. of the 5th Huntsville Gamma-Ray Burst Symposium, 5 pages, LaTe

Silicon mirror suspensions for gravitational wave detectors

One of the most significant limits to the sensitivity of current, and future, long-baseline interferometric gravitational wave detectors is thermal displacement noise of the test masses and their suspensions. This paper reports results of analytical and experimental studies of the limits to thermal noise performance of cryogenic silicon test mass suspensions set by two constraints on suspension fibre dimensions: the minimum dimensions required to allow conductive cooling for extracting incident laser beam heat deposited in the mirrors; and the minimum dimensions of fibres (set by their tensile strength) which can support test masses of the size envisaged for use in future detectors. We report experimental studies of breaking strength of silicon ribbons, and resulting design implications for the feasibility of suspension designs for future gravitational wave detectors using silicon suspension fibres. We analyse the implication of this study for thermal noise performance of cryogenically cooled silicon suspensions

Mechanical loss of a hydroxide catalysis bond between sapphire substrates and its effect on the sensitivity of future gravitational wave detectors

Hydroxide catalysis bonds are low mechanical loss joints which are used in the fused silica mirror suspensions of current room temperature interferometric gravitational wave detectors, one of the techniques which was essential to allow the recent detection of gravitational radiation by LIGO. More sensitive detectors may require cryogenic techniques with sapphire as a candidate mirror and suspension material, and thus hydroxide catalysis bonds are under consideration for jointing sapphire. This paper presents the first measurements of the mechanical loss of such a bond created between sapphire substrates and measured down to cryogenic temperatures. The mechanical loss is found to be 0.03±0.01 at room temperature, decreasing to (3±1)×10−4 at 20 K. The resulting thermal noise of the bonds on several possible mirror suspensions is presented

Jet Deflection via Cross winds: Laboratory Astrophysical Studies

We present new data from High Energy Density (HED) laboratory experiments designed to explore the interaction of a heavy hypersonic radiative jet with a cross wind. The jets are generated with the MAGPIE pulsed power machine where converging conical plasma flows are produced from a cylindrically symmetric array of inclined wires. Radiative hypersonic jets emerge from the convergence point. The cross wind is generated by ablation of a plastic foil via soft-X-rays from the plasma convergence region. Our experiments show that the jets are deflected by the action of the cross wind with the angle of deflection dependent on the proximity of the foil. Shocks within the jet beam are apparent in the data. Analysis of the data shows that the interaction of the jet and cross wind is collisional and therefore in the hydro-dynamic regime. MHD plasma code simulations of the experiments are able to recover the deflection behaviour seen in the experiments. We consider the astrophysical relevance of these experiments applying published models of jet deflection developed for AGN and YSOs. Fitting the observed jet deflections to quadratic trajectories predicted by these models allows us to recover a set of plasma parameters consistent with the data. We also present results of 3-D numerical simulations of jet deflection using a new astrophysical Adaptive Mesh Refinement code. These simulations show highly structured shocks occurring within the beam similar to what was observed in the experimentsComment: Submitted to ApJ. For a version with figures go to http://web.pas.rochester.edu/~afrank/labastro/CW/Jet-Wind-Frank.pd

Effect of heat treatment and aging on the mechanical loss and strength of hydroxide catalysis bonds between fused silica samples

Hydroxide catalysis bonds are used in the aLIGO gravitational wave detectors and are an essential technology within the mirror suspensions which allowed for detector sensitivities to be reached that enabled the first direct detections of gravitational waves. Methods aimed at further improving hydroxide catalysis bonds for future upgrades to these detectors, in order to increase detection rates and the number of detectable sources, are explored. Also, the effect on the bonds of an aLIGO suspension construction procedure involving heat, the fibre welding process, is investigated. Here we show that thermal treatments can be beneficial to improving some of the bond properties important to the mirror suspensions in interferometric gravitational wave detectors. It was found that heat treating bonds at 150\,^\circC increases bond strength by a factor of approximately 1.5 and a combination of bond ageing and heat treatment of the optics at 150\,\circC reduces the mechanical loss of a bond from 0.10 to 0.05. It is also shown that current construction procedures do not reduce bond strength